반응 #1459935

반응 방정식

phosphoryl chloride

5-chloro-1-methylindole

sodium bicarbonate

→

5-chloro-1-methylindole-3-carbaldehyde

수율 80.0%

용매

DMF

DMF

반응 조건

후처리

1. 1
   workup.ADDITIONAfter completion of the dropwise addition
2. 2
   workup.STIRRINGThe resulting mixture was stirred for cyclohexanecarboxylic time at 60° C. for 6 hours
3. 3
   추출followed by extraction with chloroform
4. 4
   세척The extract was washed with saturated brine
5. 5
   건조dried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONdistilled under reduced pressure
7. 7
   기타to remove the solvent under reduced pressure
8. 8
   기타The residue was purified by chromatography on a silica gel column, whereby from ethyl acetate eluate fractions

실험 절차

While stirring DMF (70 ml) at 0° C., phosphoryl chloride (4.97 ml, 53.3 mmol) was added dropwise in portions. After completion of the dropwise addition, the reaction mixture was stirred further for 10 minutes at the same temperature. A solution of 5-chloro-1-methylindole (5.89 g, 35.6 mmol) in DMF (10 ml) was added. The resulting mixture was stirred for cyclohexanecarboxylic time at 60° C. for 6 hours. The reaction mixture was cooled to room temperature, and added to a saturated aqueous solution of sodium bicarbonate in portions, followed by extraction with chloroform. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and distilled under reduced pressure to remove the solvent under reduced pressure. The residue was purified by chromatography on a silica gel column, whereby from ethyl acetate eluate fractions, 5-chloro-1-methylindole-3-carbaldehyde (5.51 g, 80%) was obtained as a colorless solid.

출처