반응 #1458415

ord-1bc0273f6d9e4898b5a2d888224182f6

반응 방정식

CC(=O)Oc1ccc(Cl)cc1
p-chlorophenyl acetate
C=C(C)OC(C)=O
isopropenyl acetate
CC(=O)O[C@H](C)c1ccccc1
(R)-1-phenylethyl acetate
수율 95.0%

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타used in Example 1 over a reaction period of 42 hours

실험 절차

The procedure of Example 1 was repeated except that 3 molar equivalents of p-chlorophenyl acetate (a conventional acylating agent) was used in place of isopropenyl acetate in the presence of three times the amount of the enzyme catalyst used in Example 1 over a reaction period of 42 hours, to obtain (R)-1-phenylethyl acetate having an optical purity of higher than 99%, at a yield of 95%.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07156731B2uspto-grants-2007_01