반응 #1457348

반응 방정식

sodium acetate

sodium hypochloride

chlorine

2-allyl-6-chlorobenzaldehyde oxime

→

8-Chloro-3a,4-dihydro-3H-indeno[1,2-c]isoxazol

용매

methylene chloride

반응 조건

후처리

1. 1
   기타the organic phase was separated off
2. 2
   추출the aqueous phase was extracted with methylene chloride
3. 3
   세척the combined organic phases were washed with saturated ammonium chloride solution
4. 4
   기타dried
5. 5
   기타the solvent was removed

실험 절차

At room temperature, 37.0 ml of a sodium hypochloride [sic] solution (12.5% of active chlorine) were added dropwise to a solution of 8.4 g (42.9 mmol) of 2-allyl-6-chlorobenzaldehyde oxime in 100 ml of methylene chloride, and a spatula tip of sodium acetate was added. The mixture was stirred at room temperature for 2 hours, the organic phase was separated off, the aqueous phase was extracted with methylene chloride and the combined organic phases were washed with saturated ammonium chloride solution and dried, and the solvent was removed. This gave 7.0 g (94%) of 8-chloro-3a,4-dihydro-3H-indeno[1,2-c]isoxazol in the form of a viscous oil.

출처