반응 #1447133

반응 방정식

dimethylamine

2-bromo-1-(4-bromophenyl)ethanone

→

title compound

수율 86.0%

1-(4-Bromophenyl)-2-(dimethylamino)ethanone

수율 86.0%

용매

methanol

tetrahydrofuran

반응 조건

후처리

1. 1
   기타The solvent was removed by distillation
2. 2
   기타the residue was then purified by column chromatography on silica gel (hexane:ethyl acetate=10:1 to 0:100)

실험 절차

A 2.0 M solution of dimethylamine (0.5 mmol) in methanol was added to a solution of 2-bromo-1-(4-bromophenyl)ethanone (114.5 mg, 0.41 mmol) in tetrahydrofuran (2 ml), and the mixture was stirred at room temperature for 15 min. The solvent was removed by distillation, and the residue was then purified by column chromatography on silica gel (hexane:ethyl acetate=10:1 to 0:100) to give 84.7 mg (yield 86%) of the title compound.

출처