반응 #1447124

반응 방정식

N-[2-(3,3-dimethylbut-1-ynyl)phenyl]acetamide

hydrogen

→

N-[2-(3,3-dimethylbutyl)phenyl]acetamide

수율 94.2%

용매

methanol

반응 조건

후처리

1. 1
   기타Removal of the catalyst

실험 절차

3.23 g (15 mmol) of N-[2-(3,3-dimethylbut-1-ynyl)phenyl]acetamide (XIII-1) were initially charged in 40 ml of methanol. 0.5 g of palladium-on-carbon (5%) was added, and the mixture is then hydrogenated in an autoclave at a hydrogen pressure of 4 bar for 20 h. Removal of the catalyst and the solvent gave 3.1 g (94% of theory) of N-[2-(3,3-dimethylbutyl)phenyl]acetamide of logP (pH 2.3)=2.69.

출처