반응 #1447123

반응 방정식

1-(2-aminophenyl)-3-methylbutan-1-one

hydrazine hydrate

water

potassium hydroxide

→

[2-(3-methylbutyl)-phenyl]amine

수율 72.1%

용매

ethyl acetate

triethylene glycol

반응 조건

후처리

1. 1
   세척The organic phase is again washed with water
2. 2
   건조dried over magnesium sulphate
3. 3
   농축concentrated under reduced pressure
4. 4
   기타Purification by column chromatography (cyclohexane/ethyl acetate 3:1)

실험 절차

A solution comprising 8.0 g (0.045 mol) of 1-(2-aminophenyl)-3-methylbutan-1-one (X-1), 6.8 g (0.135 mol) of hydrazine hydrate and 7.6 g (0.135 mol) of potassium hydroxide in 90 ml of triethylene glycol is heated at 210° C. for 6 h. For work-up, water and ethyl acetate are added at room temperature. The organic phase is again washed with water, dried over magnesium sulphate and concentrated under reduced pressure. Purification by column chromatography (cyclohexane/ethyl acetate 3:1) gives 5.3 g (71.5% of theory) of [2-(3-methylbutyl)-phenyl]amine.

출처