반응 #1447122

반응 방정식

[2-(3-methylbutyl)phenyl]amine

5-fluoro-1,3-dimethyl-1H-pyrazole-4-carbonyl chloride

triethylamine

→

5-fluoro-1,3-dimethyl-N-[2-(3-methylbutyl)phenyl]-1H-pyrazole-4-carboxamide

수율 98.0%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   여과filtered through silica gel
2. 2
   농축concentrated

실험 절차

326.5 mg (2.0 mmol) of [2-(3-methylbutyl)phenyl]amine (III-1) are added to a solution comprising 388.5 mg (2.2 mmol) of 5-fluoro-1,3-dimethyl-1H-pyrazole-4-carbonyl chloride and 0.45 ml (3.2 mmol) of triethylamine in 20 ml of tetrahydrofuran. The reaction solution is stirred at 60° C. for 90 min, filtered through silica gel and concentrated. Column chromatography (cyclohexane/ethyl acetate gradient) gives 592 mg (98% of theory) of 5-fluoro-1,3-dimethyl-N-[2-(3-methylbutyl)phenyl]-1H-pyrazole-4-carboxamide of logP (pH 2.3)=3.12.

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