반응 #1447112

반응 방정식

Et3N

1-naphthyl dichlorophosphate

(25)-1-butoxy-1-oxopropan-2-aminium chloride

→

n-Butyl N-[chloro(1-naphthyloxy)phosphoryl]-L-alaninate

용매

DCM

반응 조건

후처리

1. 1
   workup.WAITthe reaction was left
2. 2
   온도to warm to RT overnight
3. 3
   기타All volatiles were removed
4. 4
   세척the resulting white solid was washed with Et2O
5. 5
   여과filtered
6. 6
   기타evaporated in vacuo
7. 7
   기타to obtain a colorless oil
8. 8
   workup.ADDITIONas a 1:1 mixture of diastereoisomers

실험 절차

To 1-naphthyl dichlorophosphate in DCM (0.086 M) was added (25)-1-butoxy-1-oxopropan-2-aminium chloride (1.0 eq.). After cooling to −78° C., neat Et3N (2.0 eq.) was added and the reaction was left to warm to RT overnight. All volatiles were removed and the resulting white solid was washed with Et2O, filtered and evaporated in vacuo to obtain a colorless oil as a 1:1 mixture of diastereoisomers. 31P NMR (400 MHz, CDCl3): δ 8.39 and 8.11 ppm.

출처