반응 #1447102

반응 방정식

KOtBu

1-Bromo-4-cyano-3-fluoro-5-(4-ethyl-phenyl)-benzene

KOtBu

HCl

cyclobutanol

→

title compound

1-Bromo-4-cyano-3-cyclobutoxy-5-(4-ethyl-phenyl)-benzene

반응 조건

후처리

1. 1
   workup.ADDITIONcharged with a stir bar
2. 2
   workup.ADDITIONis added
3. 3
   추출The resulting mixture is extracted with ethyl acetate
4. 4
   건조the combined organic phases are dried (sodium sulphate)
5. 5
   기타the solvent is removed

실험 절차

1-Bromo-4-cyano-3-fluoro-5-(4-ethyl-phenyl)-benzene (1.2 g) is added to a flask charged with a stir bar, KOtBu (0.5 g) and cyclobutanol (3.0 g). The solution is stirred at room temperature overnight, before another portion of KOtBu (0.2 g) is added. The solution is stirred for another 5 h and then neutralized with 1 M aqueous HCl solution. The resulting mixture is extracted with ethyl acetate, the combined organic phases are dried (sodium sulphate) and the solvent is removed to give the title compound.

출처