반응 #1447098

반응 방정식

hydrochloric acid

N-[4-bromo-2-(4-ethyl-benzyl)-5-methoxy-phenyl]-acetamide

→

title compound

4-Bromo-2-(4-ethyl-benzyl)-5-methoxy-phenylamine

용매

isopropanol

반응 조건

후처리

1. 1
   온도The solution is heated
2. 2
   온도at reflux temperature for 8 h
3. 3
   농축concentrated under reduced pressure
4. 4
   기타to remove most of the alcohol
5. 5
   workup.ADDITIONAqueous NaHCO3 solution is added to the rest
6. 6
   추출the resulting mixture is extracted twice with ethyl acetate
7. 7
   세척The combined organic extracts are washed with brine
8. 8
   건조dried (Na2SO4)
9. 9
   농축concentrated

실험 절차

Half-concentrated hydrochloric acid (5 mL) is added to a solution of N-[4-bromo-2-(4-ethyl-benzyl)-5-methoxy-phenyl]-acetamide (2.8 g) in isopropanol (20 mL). The solution is heated at reflux temperature for 8 h and then concentrated under reduced pressure to remove most of the alcohol. Aqueous NaHCO3 solution is added to the rest and the resulting mixture is extracted twice with ethyl acetate. The combined organic extracts are washed with brine, dried (Na2SO4) and concentrated to give the title compound.

출처