반응 #1447093

반응 방정식

water

Sodium methoxide

(2-bromo-4-fluoro-phenyl)-(4-ethyl-phenyl)-methanone

sodium methoxide

→

(2-Bromo-4-methoxy-phenyl)-(4-ethyl-phenyl)-methanone

용매

DMF

반응 조건

후처리

1. 1
   workup.ADDITIONis added
2. 2
   추출the resulting mixture is extracted with ethyl acetate
3. 3
   건조The organic phase is dried (sodium sulphate)
4. 4
   기타the solvent is removed
5. 5
   기타the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1)

실험 절차

Sodium methoxide (10.5 g) is added portionwise to (2-bromo-4-fluoro-phenyl)-(4-ethyl-phenyl)-methanone (43.0 g) dissolved in DMF (200 mL). The solution is stirred overnight, before another portion of sodium methoxide (5.5 g) is added. After another 3 h of stirring, water is added and the resulting mixture is extracted with ethyl acetate. The organic phase is dried (sodium sulphate), the solvent is removed and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1).

출처