반응 #1441956

반응 방정식

Diethylzinc

trifluoroacetic acid

4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine

diiodomethane

hydrochloric acid

→

6-(4-Fluorophenyl)-3-azabicyclo[4.1.0]heptane

용매

dichloromethane

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   기타the phases were separated
2. 2
   세척the organic phase was washed with water
3. 3
   건조dried over magnesium sulfate
4. 4
   농축concentrated
5. 5
   기타This resulted in the product with the molecular weight of 191.25 (C12H14FN)

실험 절차

Diethylzinc (1M in hexane, 19 ml) in dichloromethane (100 ml) was mixed with trifluoroacetic acid (3 ml) at 0° C. After 20 minutes, diiodomethane (3 ml) in dichloromethane (10 ml) was added. Then 4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine (3.0 g) in dichloromethane (10 ml) was added, and the mixture was stirred at room temperature overnight. After addition of hydrochloric acid (1N), the phases were separated and the organic phase was washed with water, dried over magnesium sulfate and concentrated. This resulted in the product with the molecular weight of 191.25 (C12H14FN); MS(ESI): 192 (M+H+).

출처