반응 #1435731

반응 방정식

hydrochloric acid

water

water

ethyl (2-chloro-6-fluorophenyl)acetoacetate

aminoimidazole hydrochloride

1,5-diazabicyclo[4.3.0]-5-nonene

→

5-hydroxy-6-(2-chloro-6-fluorophenyl)-7-methylimidazo[1,2-a]pyrimidine

용매

chloroform

N,N-dimethylformamide

반응 조건

후처리

1. 1
   온도to cool
2. 2
   여과the precipitate was filtered

실험 절차

A mixture of 1.29 g of ethyl (2-chloro-6-fluorophenyl)acetoacetate, 0.60 g of aminoimidazole hydrochloride, 1.24 g of 1,5-diazabicyclo[4.3.0]-5-nonene (DBN) and 5 ml of N,N-dimethylformamide was heated at 100° C. for 14 hours. The reaction mixture was allowed to cool, and chloroform and water were added thereto. To the separated water layer, conc. hydrochloric acid was added and the precipitate was filtered, which was followed to subject to silica gel chromatography to give 0.16 g of 5-hydroxy-6-(2-chloro-6-fluorophenyl)-7-methylimidazo[1,2-a]pyrimidine.

출처