반응 #1435725

반응 방정식

diethyl (2,4,6-trifluorophenyl)malonate

2-aminoimidazole hydrochloride

DBU

N,N-dimethylformamide

→

5,7-dihydroxy-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine

수율 78.3%

용매

water

chloroform

반응 조건

후처리

1. 1
   온도to cool to room temperature
2. 2
   농축The separated water layer was concentrated
3. 3
   workup.ADDITIONthe residue was diluted with water and conc. hydrochloric acid
4. 4
   workup.ADDITIONwas added
5. 5
   온도under ice-cooling
6. 6
   기타The precipitation
7. 7
   여과was filtered
8. 8
   기타dried

실험 절차

A mixture of 2.90 g of diethyl (2,4,6-trifluorophenyl)malonate, 2.39 g of 2-aminoimidazole hydrochloride, 4.57 g of DBU and 10 ml of N,N-dimethylformamide was heated at 100° C. for 6 hours. After allowing the reaction mixture to cool to room temperature, chloroform and water were added thereto. The separated water layer was concentrated, the residue was diluted with water and conc. hydrochloric acid was added thereto under ice-cooling. The precipitation was filtered and dried to give 2.2 g of 5,7-dihydroxy-6-(2,4,6-trifluorophenyl)imidazo[1,2-a]pyrimidine.

출처