반응 #1435697

반응 방정식

ethanol

cysteine hydrochloride

maltose

Ethanol

pyridine

→

2-(1,2,4,5-Tetrahydroxy-3-Glucopyranosyloxypentyl) Thiazolidine-4-Carboxylic acid

용매

water

반응 조건

후처리

1. 1
   workup.WAITthe solution was left
2. 2
   기타was formed
3. 3
   기타The solvent was removed by decantation
4. 4
   workup.DISSOLUTIONthe precipitate was dissolved in 100 ml of water
5. 5
   기타After the insoluble matters were removed by filtration
6. 6
   기타condensed to about 30 ml
7. 7
   workup.WAITthe solution was then left
8. 8
   기타to stand in a refrigerator overnight
9. 9
   여과The produced crystals were collected by filtration
10. 10
    workup.DISSOLUTIONThe crystals were then dissolved in water again
11. 11
    기타the insoluble matters were removed by filtration
12. 12
    기타condensed, and ethanol
13. 13
    workup.ADDITIONwas added to the solution
14. 14
    기타recrystallization
15. 15
    여과The produced crystals were collected by filtration
16. 16
    기타dried under reduced pressure
17. 17
    기타to obtain 2.2 g of a white powder (molar yield based on cysteine: 4.9%)

실험 절차

17.56 Grams (100 mmol) of cysteine hydrochloride and 34.20 g (100 mmol) of maltose were dissolved in 35 ml of pure water, 8.36 ml (100 mmol) of pyridine was then added thereto, and the resulting solution was stirred at room temperature for 72 hours. 300 Milliliters of ethanol was added to the stirred solution, and the solution was left to stand in a refrigerator, whereby a paste-like precipitate was formed. The solvent was removed by decantation, and the precipitate was dissolved in 100 ml of water. After the insoluble matters were removed by filtration, the remaining solution was condensed to about 30 ml. Ethanol was continuously added to the condensed solution until a precipitate was about to appear, and the solution was then left to stand in a refrigerator overnight. The produced crystals were collected by filtration. The crystals were then dissolved in water again, the insoluble matters were removed by filtration, the resulting solution was condensed, and ethanol was added to the solution to cause recrystallization. The produced crystals were collected by filtration and dried under reduced pressure to obtain 2.2 g of a white powder (molar yield based on cysteine: 4.9%).

출처