반응 #1412

반응 방정식

trans-3-amino-4-methylthio-pyrrolidine

pivalaldehyde

→

trans-3-(2,2-Dimethyl-propylideneamino)-4-methylthio-pyrrolidine

용매

methanol

반응 조건

후처리

1. 1
   workup.ADDITIONare added dropwise
2. 2
   기타rises from 25° to 36° C
3. 3
   온도without cooling
4. 4
   농축the batch is then concentrated
5. 5
   workup.DISTILLATIONthe residue is distilled

실험 절차

1.32 g (10 mmol) of trans-3-amino-4-methylthio-pyrrolidine are initially introduced into 5 ml of methanol, and 1.23 ml (11 mmol) of 97% strength pivalaldehyde are added dropwise, after which the temperature rises from 25° to 36° C. The mixture is subsequently stirred for a further 30 minutes, without cooling, the batch is then concentrated and the residue is distilled. Yield: 1.50 g (75% of theory),

출처