반응 #1394

반응 방정식

trimethylpyruvic acid sodium salt

hydroxylamine hydrochloride

→

trimethylpyruvic acid oxime

수율 81.2%

용매

water

반응 조건

후처리

1. 1
   기타The product crystallized out
2. 2
   온도during slow cooling under agitation
3. 3
   여과After 1.5 h agitation in an ice bath the crystals were filtered off
4. 4
   세척washed with 150 ml ice water
5. 5
   기타dried in a vacuum at 60° C.
6. 6
   건조further dried in a vacuum desiccator over phosphorus pentaoxide to constant weight

실험 절차

163 g (1 mole) 93.5% trimethylpyruvic acid sodium salt and 69.5 g (1 mole) hydroxylamine hydrochloride were dissolved at 40° C. in 450 ml water. The product crystallized out during slow cooling under agitation. After 1.5 h agitation in an ice bath the crystals were filtered off, washed with 150 ml ice water, dried in a vacuum at 60° C., and then further dried in a vacuum desiccator over phosphorus pentaoxide to constant weight. 117.8 g trimethylpyruvic acid oxime (81% yield) in the form of colorless crystals were obtained.

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