반응 #1381467

반응 방정식

methyl 2-[2-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyloxy]phenyl]acetate

tetrahydrofuran

Hydrochloric acid

sodium hydroxide

→

2-[2-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyloxy]phenyl]acetic acid

수율 96.0%

용매

methanol

water

반응 조건

후처리

1. 1
   여과the precipitated solid was collected by filtration
2. 2
   기타dried with air

실험 절차

To a mixture of methyl 2-[2-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyloxy]phenyl]acetate (0.57 g), tetrahydrofuran (3.0 mL) and methanol (3.0 mL) was added a 1N aqueous sodium hydroxide solution (2.4 mL) and the mixture was stirred at 50° C. for 1.5 hrs. 1N Hydrochloric acid (2.4 mL) and water were added to the reaction mixture, and the precipitated solid was collected by filtration and dried with air to give crystals (0.51 g, 96%) of 2-[2-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyloxy]phenyl]acetic acid. Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 141-142° C.

출처