반응 #1381263

ord-36746e833c704596986dcc9ee71cbe81

반응 방정식

Nc1ccc(O)cc1[N+](=O)[O-]
2-Nitro-4-hydroxyaniline
O=[N+]([O-])c1ccc(Cl)nc1
2-chloro-5-nitropyridine
O=C([O-])[O-].[K+].[K+]
K2CO3
→
Nc1ccc(Oc2ccc(N)c(N)c2)nc1
title compound
Nc1ccc(Oc2ccc(N)c(N)c2)nc1
5-Amino-2-(3,4-diaminophenoxy)pyridine

반응물

Nc1ccc(O)cc1[N+](=O)[O-]
2-Nitro-4-hydroxyaniline
O=[N+]([O-])c1ccc(Cl)nc1
2-chloro-5-nitropyridine
O=C([O-])[O-].[K+].[K+]
K2CO3

시약

[Pd]
Pd/C

용매

CN(C)C=O
DMF
CO
MeOH

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

2-Nitro-4-hydroxyaniline was reacted with 2-chloro-5-nitropyridine and K2CO3 in DMF at rt, followed by hydrogenation over Pd/C in MeOH, afforded the title compound; MS m/e 217 (M+1).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07238813B2uspto-grants-2007_07