반응 #1379892

반응 방정식

2,3-bis-tert-butoxycarbonylamino propionic acid benzyl ester

HCl

→

2,3-Diamino-propionic acid trihydrochloride

용매

acetonitrile

반응 조건

후처리

1. 1
   기타The solvent was removed under vacuum
2. 2
   workup.ADDITIONthe mixture was diluted with ethyl acetate (100 ml) and water (50 ml)
3. 3
   기타The layers were separated
4. 4
   기타the aqueous layer was evaporated to dryness (1.23 g of a foam/syrup)

실험 절차

A solution of 2,3-bis-tert-butoxycarbonylamino propionic acid benzyl ester (1.8 g), 4N aqueous HCl (40 ml), and acetonitrile (50 ml) was stirred for 18 hours at room temperature. The solvent was removed under vacuum, and the mixture was diluted with ethyl acetate (100 ml) and water (50 ml) and stirred for 15 minutes. The layers were separated and the aqueous layer was evaporated to dryness (1.23 g of a foam/syrup). 1H NMR (300 MHz): 3.2-3.5 (m, 2H), 4.2-4.35 (m, 1H), 5.13-5.25 (q, 2H, J=11.8, 3.1 Hz).

출처