반응 #1379886

반응 방정식

2-chloro-3-nitro-6-methoxypyridine

3-methylamino-1,2-dihydroxypropane

→

yellow powder

수율 87.1%

3-[(6-methoxy-3-nitro-2-pyridyl)methylamino]propane-1,2-diol

수율 87.1%

용매

ethanol

반응 조건

후처리

1. 1
   온도The mixture is refluxed for 2 hours
2. 2
   workup.STIRRINGwith stirring
3. 3
   기타The precipitate formed
4. 4
   여과is filtered off by suction
5. 5
   기타dried under vacuum to constant weight

실험 절차

4 g (0.0219 mol) of the product 2-chloro-3-nitro-6-methoxypyridine, 50 ml of ethanol and 4.15 ml (0.0438 mol) of 3-methylamino-1,2-dihydroxypropane are placed in a fully equipped round-bottomed flask. The mixture is refluxed for 2 hours with stirring and is then poured onto an ice/water mixture with stirring. The precipitate formed is filtered off by suction and dried under vacuum to constant weight. 4.74 g of yellow powder are obtained, ie a yield of 87.1%.

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