반응 #1379883

반응 방정식

2-methylaminoethanol

2-chloro-3-nitro-6-methoxypyridine

dioxane

→

yellow powder

수율 70.0%

2-[(6-methoxy-3-nitro-2-pyridyl)methylamino]ethanol

수율 70.0%

용매

water

반응 조건

후처리

1. 1
   온도The mixture is refluxed for 2 hours
2. 2
   workup.STIRRINGwith stirring
3. 3
   기타The precipitate formed
4. 4
   여과is filtered off by suction
5. 5
   기타dried under vacuum to constant weight

실험 절차

1.9 g (0.01 mol) of the product 2-chloro-3-nitro-6-methoxypyridine, 30 ml of dioxane, 5 ml of water and 1.6 ml (0.02 mol) of 2-methylaminoethanol are placed in a fully equipped round-bottomed flask. The mixture is refluxed for 2 hours with stirring and is then poured onto an ice/water mixture with stirring. The precipitate formed is filtered off by suction and dried under vacuum to constant weight. 1.6 g of yellow powder are obtained, ie a yield of 70%.

출처