반응 #1378

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ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-ethoxyacrylate

ethylamine

→

ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-ethylaminoacrylate

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실험 절차

Employing ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-ethoxyacrylate (1.0 g) and 70% aqueous ethylamine solution (0.24 ml), the procedure of Reference Example 8 is repeated to give ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-ethylaminoacrylate, which is then treated with 60 % sodium hydride (0.15 g) as in Reference Example 9 to give ethyl 1-ethyl-5-methyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (0.6 g), as white crystals, m.p. 157°-159° C.

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