반응 #1371

반응 방정식

diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate

p-toluenesulfonic acid

→

ethyl 2-methyl-3,4,6-trifluorobenzoylacetate

수율 82.6%

용매

water

반응 조건

후처리

1. 1
   온도the mixture is refluxed for 2.5 hours
2. 2
   온도After cooling
3. 3
   추출the resultant is extracted with diethyl ether
4. 4
   건조the extract is dried over magnesium sulfate
5. 5
   농축concentrated

실험 절차

To diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate (5.1 g) are added water (20 ml) and p-toluenesulfonic acid (30 mg) and the mixture is refluxed for 2.5 hours. After cooling, the resultant is extracted with diethyl ether, and the extract is dried over magnesium sulfate and concentrated to give ethyl 2-methyl-3,4,6-trifluorobenzoylacetate (3.3 g).

출처