반응 #1367

반응 방정식

2-methylthiomethyl-3,4,6-trifluoroaniline

→

2-methyl-3,4,6-trifluoroaniline

수율 71.3%

용매

ethanol

반응 조건

후처리

1. 1
   여과After the catalyst is filtered off
2. 2
   workup.ADDITIONthe filtrate is added with water
3. 3
   추출extracted with dichloromethane
4. 4
   건조The is dried over magnesium sulfate
5. 5
   농축concentrated

실험 절차

To 2-methylthiomethyl-3,4,6-trifluoroaniline (22.2 g) are added ethanol (400 ml) and Raney nickel (200 g) and the mixture is stirred at room temperature for 30 minutes. After the catalyst is filtered off, the filtrate is added with water and extracted with dichloromethane. The is dried over magnesium sulfate and concentrated to give 2-methyl-3,4,6-trifluoroaniline (12.3 g).

출처