반응 #1366290

ord-97c30d51081c4c9aa29822bc698dc6b3

반응 방정식

COC(=O)N[C@@H](C(=O)O)c1ccccc1
(R)-methoxycarbonylamino-phenyl-acetic acid
Cl.O=C(OCc1ccccc1)[C@@H]1CCCN1
(L)-proline benzyl ester hydrochloride
→
COC(=O)N[C@@H](C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1)c1ccccc1
title compound
수율 31.0%
COC(=O)N[C@@H](C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1)c1ccccc1
1-[(R)-Methoxycarbonylamino-phenyl-acetyl]-pyrrolidine-2-(S)-carboxylic acid benzyl ester
수율 31.0%
COC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1)c1ccccc1
1-[(S)-methoxycarbonylamino-phenyl-acetyl]-pyrrolidine-2-(S)-carboxylic acid benzyl ester
수율 15.0%

반응물

COC(=O)N[C@@H](C(=O)O)c1ccccc1
(R)-methoxycarbonylamino-phenyl-acetic acid
Cl.O=C(OCc1ccccc1)[C@@H]1CCCN1
(L)-proline benzyl ester hydrochloride

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Reaction of 1.0 g of (R)-methoxycarbonylamino-phenyl-acetic acid and 1.16 g of (L)-proline benzyl ester hydrochloride according to the procedure described in example 91b gave 0.59 g (31%) of the title compound as a white solid and 0.28 g (15%) of 1-[(S)-methoxycarbonylamino-phenyl-acetyl]-pyrrolidine-2-(S)-carboxylic acid benzyl ester (+)-APCI-MS: 397 (MH+).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06444672B1uspto-grants-2002_09