반응 #1361590

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4-(7-chloroquinolin-4-yl)butyn-1-ol

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title compound

수율 49.1%

4-(7-Chloroquinolin-4-yl)butan-1-ol

수율 49.1%

용매

ethanol

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후처리

1. 1
   workup.ADDITIONwas added
2. 2
   기타to be consumed by TLC
3. 3
   기타The spent catalyst was removed by filtration through a Celite pad
4. 4
   세척the pad carefully washed with more ethanol
5. 5
   기타The combined filtrates were evaporated in vacuo
6. 6
   기타the residue purified by flash chromatography on silica gel (ethyl acetate

실험 절차

4-(7-chloroquinolin-4-yl)butyn-1-ol (1 g) was dissolved in ethanol (25 mL) in a Parr hydrogenation bottle and platinum (IV) oxide [Adams' Catalyst] (100 mg) was added. The Parr bottle was placed on a Parr hydrogenation apparatus and the solution hydrogenated at 50 psi for 2 hours after which time the starting material had been judged to be consumed by TLC. The spent catalyst was removed by filtration through a Celite pad and the pad carefully washed with more ethanol. The combined filtrates were evaporated in vacuo and the residue purified by flash chromatography on silica gel (ethyl acetate; then ethyl acetate:methanol, 95:5) to give the title compound (500 mg).

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