반응 #1361380

반응 방정식

Water

Triflic anhydride

product

6-[7-[N-[(2,4-Dimethoxyphenyl)methyl]-(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5 d]pyrimidin-3-yl]-tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol

pyridine

dichloromethane

→

sub-title compound

3-Amino-5-[7-[(2-phenylcyclopropyl)amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-cyclopentane-1,2-diol, hydrochloride

반응 조건

후처리

1. 1
   추출the mixture was extracted with dichloromethane
2. 2
   건조The organic layer was dried (MgSO4)
3. 3
   기타evaporated
4. 4
   기타purified (SiO2, petrol:ether 3:2 as eluent)

실험 절차

Triflic anhydride (0.08 ml) was added to a solution of the product from step (h) (147 mg) and pyridine (0.08 ml) in dichloromethane (2 ml) and stirred for 18 hours. Water was added and the mixture was extracted with dichloromethane. The organic layer was dried (MgSO4), evaporated and purified (SiO2, petrol:ether 3:2 as eluent) to give the sub-title compound as a white foam (166 mg).

출처