반응 #1355603
ord-22306e1e2c224838b9e56104ecd27b1e
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1여과was filtered
- 2세척The filtrate was washed with dilute hydrochloric acid, water and saturated sodium chloride solution
- 3기타The solution was dried
- 4농축concentrated
- 5기타purified
- 6기타by dry column chromatography
실험 절차
A solution of z,z,z-octadeca-6,9,12-trienoic acid (150 g) in methylene chloride (500 ml) was added dropwise to a mixture of 1,3-dihydroxypropane (205 g), 1,3-dicyclohexylcarbodiimide (130 g) and 4-(N,N-dimethylamino)pyridine (87 g) in methylene chloride (2500 ml) at room temperature under nitrogen. When tlc indicated that the reaction had gone to completion the reaction mixture was filtered. The filtrate was washed with dilute hydrochloric acid, water and saturated sodium chloride solution. The solution was dried, concentrated and purified by dry column chromatography to yield 1-(z,z,z-octadeca-6,9,12-trienoyloxy)-3-hydroxypropane as a pale yellow oil.