반응 #1354501

반응 방정식

4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzaldehyde

sodium pyruvate

sodium carbonate

water

→

(E)-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzylidenepyruvic acid

수율 44.5%

용매

methanol

반응 조건

후처리

1. 1
   온도under reflux
2. 2
   농축The reaction mixture was concentrated
3. 3
   온도under reflux to about ⅓ of the initial volume
4. 4
   추출The concentrate was subjected to extraction with ethyl acetate
5. 5
   여과Resulting crystalline precipitate was collected by filtration

실험 절차

A mixture of 4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzaldehyde (2.9 g), sodium pyruvate (3.3 g), sodium carbonate (3.2 g), water (80 ml) and methanol (80 ml) was stirred for 6 hours under reflux. The reaction mixture was concentrated under reflux to about ⅓ of the initial volume. The concentrate was subjected to extraction with ethyl acetate. The aqueous layer was acidified with conc. HCl. Resulting crystalline precipitate was collected by filtration to obtain (E)-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzylidenepyruvic acid (1.6 g, 44%). Recrystallization from chloroform-methanol gave colorless needles, m.p.197-198° C.

출처