반응 #1354128

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sodium 3-methoxy-4-(4′-methylphenylsulfonyloxy)-benzenesulfonate

triphenylsulfonium chloride

→

triphenylsulfonium 3-methoxy-4-(4′-methylphenyl-sulfonyloxy)benzenesulfonate

수율 56.0%

용매

dichloromethane

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후처리

1. 1
   기타The organic layer was separated
2. 2
   세척washed with 400 g of water
3. 3
   농축concentrated in vacuum
4. 4
   기타The residue, 150 g, was purified by silica gel column chromatography (eluent, dichloromethane/methanol)

실험 절차

The sodium 3-methoxy-4-(4′-methylphenylsulfonyloxy)-benzenesulfonate crude product obtained in Synthesis Example 1, 90 g, was added to the aqueous triphenylsulfonium chloride solution obtained in Synthesis Example 2 and 400 g of dichloromethane, which was stirred for one hour at room temperature. The organic layer was separated, washed with 400 g of water, and concentrated in vacuum. The residue, 150 g, was purified by silica gel column chromatography (eluent, dichloromethane/methanol), obtaining the end product, triphenylsulfonium 3-methoxy-4-(4′-methylphenyl-sulfonyloxy)benzenesulfonate as an oily matter in an amount of 69 g (yield 56%).

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