반응 #1353606

ord-3bd6d7025ef946f3a942420ab70d1dea

반응 방정식

CCOC(=O)C(O)(CC(C)(C)c1ccc(Br)c(OC)c1)C(F)(F)F
4-(4-bromo-3-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeric acid ethyl ester
C=[C](OCC)[Sn]([CH2]CCC)([CH2]CCC)[CH2]CCC
tributyl-1-ethoxyvinyltin
CN(C)C=O
dimethylformamide
Cc1ccccc1P(c1ccccc1C)c1ccccc1C
tri-o-tolylphosphine
→
COc1cc(C(C)(C)CC(O)(C(=O)O)C(F)(F)F)ccc1C(C)=O
4-(4-Acetyl-3-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeric acid

반응물

—
bis-tri-o-tolylphosphine palladium(II) chloride
CCOC(=O)C(O)(CC(C)(C)c1ccc(Br)c(OC)c1)C(F)(F)F
4-(4-bromo-3-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeric acid ethyl ester
C=[C](OCC)[Sn]([CH2]CCC)([CH2]CCC)[CH2]CCC
tributyl-1-ethoxyvinyltin
CN(C)C=O
dimethylformamide
Cc1ccccc1P(c1ccccc1C)c1ccccc1C
tri-o-tolylphosphine

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타to 120° C.

실험 절차

Analogously to the compound above of 4-(4-bromo-3-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeric acid ethyl ester, tributyl-1-ethoxyvinyltin, tri-o-tolylphosphine and bis-tri-o-tolylphosphine-palladium(II) chloride in dimethylformamide to 120° C., oil.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06548534B2uspto-grants-2003_04