반응 #1350576

반응 방정식

3-methoxyphenylacetyl chloride

3-(3-aminophenyl)-4-bromo-1-methylpyrazole

triethylamine

→

title compound

수율 19.0%

N-[3-(4-bromo-1-methylpyrazol-3-yl)phenyl]-2-(3-methoxyphenyl)acetamide

수율 19.0%

용매

dichloromethane

dichloromethane

brine

반응 조건

후처리

1. 1
   세척The organic layer was washed with more brine
2. 2
   건조then dried over magnesium sulphate
3. 3
   농축concentrated in vacuo
4. 4
   기타The crude product was purified by column chromatography (ethyl acetate-toluene, 1:1)

실험 절차

A solution of 3-methoxyphenylacetyl chloride (0.02 ml, 0.12 mmol) in dichloromethane (0.75 ml) was added dropwise at 0° C. to a solution of 3-(3-aminophenyl)-4-bromo-1-methylpyrazole (30 mg, 0.12 mmol) and triethylamine (0.02 ml, 0.13 mmol) in dichloromethane (0.75 ml). The resulting mixture was stirred at room temperature for 16 h and then poured into brine. The organic layer was washed with more brine then dried over magnesium sulphate and concentrated in vacuo. The crude product was purified by column chromatography (ethyl acetate-toluene, 1:1), giving the title compound (9 mg, 19%). Rf 0.30 (ethyl acetate-toluene, 1:1).

출처