반응 #1350573
ord-8bbe7d95bed14770ab62d7c346039e9d
반응 방정식
4-chlorobenzoyl chloride
3-(3-aminophenyl)-4-bromo-1-methylpyrazole
triethylamine
→
title compound
수율 73.6%
N-[3-(4-bromo-1-methylpyrazol-3-yl)phenyl][4-chlorophenyl]carboxamide
수율 73.6%
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1농축concentrated
실험 절차
To 4-chlorobenzoyl chloride (15 mg, 0.08 mmol) in CH2Cl2 (1 mL) was added dropwise a solution of 3-(3-aminophenyl)-4-bromo-1-methylpyrazole (21 mg, 0.08 mmol) and triethylamine (12 μL, 0.08 mmol) in CH2Cl2 (0.5 mL). The mixture was stirred for 16 h and concentrated. Chromatography on flash silica (50% EtOAc/hexane) gave the title compound as a colourless solid (23 mg, 72%), m.p. 184.4-184.8° C. (EtOAc/hexane).