반응 #1350570
ord-318c4e9e02ea4fdf9942c5ed5ded83c8
반응 방정식
4-methoxyphenylchloroformate
3-(3-aminophenyl)-4-bromo-1-methylpyrazole
triethylamine
→
title compound
수율 59.7%
N-[3-(4-bromo-1-methylpyrazol-3-yl)phenyl][4-methoxyphenoxy]carboxamide
수율 59.7%
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1농축concentrated
실험 절차
To 4-methoxyphenylchloroformate (19 mg, 0.10 mmol) in CH2Cl2 (0.5 mL) was added dropwise a solution of 3-(3-aminophenyl)-4-bromo-1-methylpyrazole (25 mg, 0.10 mmol) and triethylamine (14 μL, 0.10 mmol) in CH2Cl2 (0.5 mL). The mixture was stirred for 16 h and concentrated. Chromatography on flash silica (40% EtOAc/hexane) gave the title compound as a colourless solid (24 mg, 526), m.p. 140.3-141.8° C. (EtOAc/hexane).