반응 #1343247

반응 방정식

2-fluoro-4-nitrobenzene-1-sulfonyl chloride

6-amino-5-fluorobenzo[c][1,2]oxaborol-1(3H)-ol

pyridine

→

title compound

수율 89.3%

2-Fluoro-N-(5-fluoro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-4-nitrobenzenesulfonamide

수율 89.3%

용매

ACN

반응 조건

후처리

1. 1
   기타After quenched with water
2. 2
   기타the solvent was removed in vacuo
3. 3
   추출The residue was extracted with ethyl acetate three times
4. 4
   세척washed with water and brine
5. 5
   건조The organic layer was dried over Na2SO4
6. 6
   농축concentrated

실험 절차

To a stirred solution of 2-fluoro-4-nitrobenzene-1-sulfonyl chloride (1.336 g, 5.57 mmol) and 6-amino-5-fluorobenzo[c][1,2]oxaborol-1(3H)-ol (0.93 g, 5.57 mmol) in 20 mL of ACN was added pyridine (900 uL, 11.14 mmol) dropwise. The reaction mixture was stirred at room temperature for 16 hours. After quenched with water, the solvent was removed in vacuo. The residue was extracted with ethyl acetate three times, and washed with water and brine. The organic layer was dried over Na2SO4, and concentrated to give 1.84 g of the title compound as a yellow residue. MS calcd for (C13H9BF2N2O6S): 370.0. MS found (ESI negative): (M−H)−=368.9

출처