반응 #1340557

반응 방정식

sodium hydroxide

3-(3-trifluoromethylphenyl)propanal

(R)-1-(1-naphthyl)ethylamine

sodium triacetoxyborohydride

→

(R)—N-(3-(3-trifluoromethylphenyl)propyl)-1-(1-naphthyl)ethylamine

용매

acetic acid

dichloromethane

water

반응 조건

후처리

1. 1
   workup.STIRRINGthe mixture had been stirred for 3 hours
2. 2
   기타the resultant was separated into an aqueous layer
3. 3
   추출The aqueous layer was extracted with dichloromethane
4. 4
   건조dried over anhydrous sodium sulfate
5. 5
   농축concentrated under reduced pressure
6. 6
   기타The residue was purified with column chromatography (silica gel/hexane:ethyl acetate of 4:1 to 1:1)
7. 7
   농축concentrated

실험 절차

To a mixture of 2.12 g of 3-(3-trifluoromethylphenyl)propanal synthesized in the Step 2, 2.0 ml of (R)-1-(1-naphthyl)ethylamine, 3.42 g of sodium triacetoxyborohydride, and 150 ml of dry dichloromethane was added 0.750 ml of glacial acetic acid, and the mixture was stirred at room temperature for 5 hours. After 100 ml of water had been added and the mixture had been stirred for 3 hours, 100 ml of 2M sodium hydroxide aqueous solution was added, and the resultant was separated into an aqueous layer and an organic layer. The aqueous layer was extracted with dichloromethane, and the extract was combined with the separated organic layer, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was purified with column chromatography (silica gel/hexane:ethyl acetate of 4:1 to 1:1) and then concentrated to afford 3.41 g of (R)—N-(3-(3-trifluoromethylphenyl)propyl)-1-(1-naphthyl)ethylamine as an oil. The compound was dissolved in 10 ml of dichloromethane, 5 ml of 4M hydrochloric acid/dioxane and 20 ml of toluene were added, and the mixture was concentrated under reduced pressure to pureness. The residue was recrystallized from 40 ml of ethanol and 200 ml of heptane to afford 1.71 g of the captioned compound.

출처