반응 #1335772

반응 방정식

methyl 9-(2'-hydroxy-3',4'-dimethoxy-6'-methylbenzoyl)nonanoate

hydrogen

→

methyl 10-(2'-hydroxy-3',4'-dimethoxy-6'-methylphenyl)decanoate

용매

acetic acid

반응 조건

후처리

1. 1
   기타The catalyst was removed by filtration
2. 2
   workup.DISTILLATIONthe acetic acid was distilled off under reduced pressure
3. 3
   세척The residue was subjected to column chromatography on silicic acid (6 parts) and elution

실험 절차

A solution of methyl 9-(2'-hydroxy-3',4'-dimethoxy-6'-methylbenzoyl)nonanoate (formula II-1 wherein R=H3CO, X=H, Y=OH, n=8, in the form of methyl ester) (0.12 part) in acetic acid (17 volume parts) was shaken with 5% palladium-on-carbon in a current of hydrogen gas at 50°-60° C. The catalyst was removed by filtration and the acetic acid was distilled off under reduced pressure. The residue was subjected to column chromatography on silicic acid (6 parts) and elution was carried out with chloroform. The procedure provided methyl 10-(2'-hydroxy-3',4'-dimethoxy-6'-methylphenyl)decanoate (formula II-2 wherein R=H3CO, X=H, Y=OH, n=8, in the form of methyl ester) (0.09 part) as a colorless oil.

출처