반응 #1334148

반응 방정식

N-[2-(N-{4-[(methoxymethyl)-cyclopropyl]phenyl}carbamoyl)-phenyl]-N-(4-pyridylmethyl)acetamide

HCl

NaHCO3

→

title compound

N-{4-[(methoxymethyl)cyclobutyl]phenyl}{2-[(4-pyridylmethyl)amino]phenyl}-carboxamide

용매

EtOH

반응 조건

후처리

1. 1
   기타evaporated with silica gel
2. 2
   기타purified by column chromatography

실험 절차

A mixture of N-[2-(N-{4-[(methoxymethyl)-cyclopropyl]phenyl}carbamoyl)-phenyl]-N-(4-pyridylmethyl)acetamide (100 mg) and 20% HCl (5 ml) in EtOH (15 ml) was stirred at 80° C. overnight. The solution was basified with NaHCO3 and evaporated with silica gel and purified by column chromatography to give the title compound. Mass: (M+1), 402.

출처