반응 #1333

반응 방정식

ethyl bromoacetate

ethyl 4-[(5,6,7,8-tetrahydro-8,8-dimethyl-5-oxonaphth-2-yl)ethynyl]benzoate

Compound 1

ethyl 4-[(5,6,7,8-tetrahydro-8,8-dimethyl-5-oxonaphth-2-yl)ethynyl]benzoate

→

title compound

Ethyl 4-[(5,6,7,8-tetrahydro-5-hydroxy-8,8-dimethyl-5-carboethoxymethylnaphth-2-yl)ethynyl]benzoate

용매

benzene

반응 조건

후처리

1. 1
   세척by washing with 2% HCl, water, 95% ethanol, acetone, anhydrous Et2O
2. 2
   건조dried in vacuum for several hours) in 20 ml of dry benzene
3. 3
   workup.ADDITIONwas slowly added
4. 4
   온도The resulting mixture was refluxed for 2 hours
5. 5
   여과the precipitate filtered through celite
6. 6
   세척The filtrate was washed with cold 15% H2SO4, sat. aqueous NaHCO3 and brine
7. 7
   건조The organic phase was dried over Na2SO4
8. 8
   농축concentrated in vacuo to a yellow oil
9. 9
   기타Purification by flash chromatography (silica, 10% EtOAc-hexane)

실험 절차

To a refluxing solution of 1.00 g (15.30 mmol) of 20 mesh, granular zinc (activated prior to use by washing with 2% HCl, water, 95% ethanol, acetone, anhydrous Et2O and then dried in vacuum for several hours) in 20 ml of dry benzene was slowly added a mixture of 0.23 ml (1.62 mmol) of ethyl bromoacetate, 0.28 g (0.81 mmol) of ethyl 4-[(5,6,7,8-tetrahydro-8,8-dimethyl-5-oxonaphth-2-yl)ethynyl]benzoate (Compound 1) in 10 ml of dry benzene. The resulting mixture was refluxed for 2 hours, cooled to room temperature and the precipitate filtered through celite. The filtrate was washed with cold 15% H2SO4, sat. aqueous NaHCO3 and brine. The organic phase was dried over Na2SO4 and concentrated in vacuo to a yellow oil. Purification by flash chromatography (silica, 10% EtOAc-hexane) yielded the title compound as a light yellow solid.

출처