반응 #1287438

반응 방정식

ketal

1-(1,3-dioxolan-2-yl)-3-hydroxybenzene

2-chloromethylquinoline

cesium carbonate

→

crystalline solid

수율 74.0%

2-[[3-(1,3-dioxolan-2-yl)phenoxy]methyl]quinoline

수율 74.0%

용매

acetone

반응 조건

후처리

1. 1
   여과The solution is filtered through Celite and silica gel
2. 2
   기타the solvent is removed in vacuo
3. 3
   기타The resulting crude solid is recrystallized

실험 절차

A solution of the ketal of Step A, above, (10 g, 0.06 mol), 2-chloromethylquinoline (10.6 g, 0.06 mol), cesium carbonate (20.0 g, 0.06 mol) and potassium iodide (0.16 g, 0.001 mol) in 250 ml acetone is refluxed 20 hours. The solution is filtered through Celite and silica gel and the solvent is removed in vacuo. The resulting crude solid is recrystallized using 2-propanol to give 13.7 g of crystalline solid (74% yield) m.p. 67°-69° C.

출처