반응 #1287437

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3-hydroxybenzaldehyde

ethylene glycol

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title product

수율 64.4%

1-(1,3-dioxolan-2-yl)-3-hydroxybenzene

수율 64.4%

용매

toluene

반응 조건

후처리

1. 1
   기타The flask is equipped with a Dean-Stark trap
2. 2
   온도the mixture is refluxed for 2 days
3. 3
   추출extracted with saturated sodium bicarbonate solution
4. 4
   기타the organic phase separated
5. 5
   건조dried (MgSO4)
6. 6
   여과Filtration and evaporation of solvent

실험 절차

To a solution of 3-hydroxybenzaldehyde (91.6 g, 0.75 mol) in 500 ml toluene is added ethylene glycol (333.0 g, 5.3 mol) and p-toluenesulfonic acid (0.19 g, 0.001 mol). The flask is equipped with a Dean-Stark trap and the mixture is refluxed for 2 days, extracted with saturated sodium bicarbonate solution and the organic phase separated and dried (MgSO4). Filtration and evaporation of solvent gives the title product as an oil (80.3 g, 64% yield).

출처