반응 #1286637

반응 방정식

potassium carbonate

hydrochloric acid

compound

2-(2-Hydroxy-5-nitrophenyl)-4-methoxy pyridine

N,N-dimethylaminothiocarbamoyl chloride

potassium carbonate

→

sub-title compound

2-(2-Hydroxy-5-nitrophenyl)-4-methoxypyridine N,N-dimethylthiocarbamate

용매

dimethyl formamide

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate (3 times)
2. 2
   세척The combined extracts were washed with water (4 times)
3. 3
   건조dried (anhydrous sodium sulphate)
4. 4
   기타evaporated
5. 5
   기타to yield a brown solid, which
6. 6
   기타was triturated with ether
7. 7
   여과filtered

실험 절차

The compound from step (a) above (24.2 mmol), N,N-dimethylaminothiocarbamoyl chloride (37 mmol) in dimethyl formamide (250 ml) were stirred rapidly in the presence of potassium carbonate (60 mmol) for 24 hours, adding more potassium carbonate (1 g) after 18 hours. The mixture was acidified (to pH4) with dilute hydrochloric acid and extracted with ethyl acetate (3 times). The combined extracts were washed with water (4 times), dried (anhydrous sodium sulphate) and evaporated to yield a brown solid, which was triturated with ether, and filtered to give the sub-title compound.

출처