반응 #1285220

ord-145ba8a02c4c410d8e4502e36c019625

반응 방정식

CCCCCCCCCCCC(C)=O
2-tridecanone
CC(C)c1cccc(C(C)C)c1N=C=O
2,6-diisopropylphenyl isocyanate
CC(C)[N-]C(C)C.[Li+]
lithium diisopropylamide
→
CCCCCCCCCCCC(=O)CC(=O)Nc1c(C(C)C)cccc1C(C)C
desired product
수율 65.0%
CCCCCCCCCCCC(=O)CC(=O)Nc1c(C(C)C)cccc1C(C)C
N-[2,6-bis(1-methylethyl)phenyl]-3-oxo-tetradecanamide
수율 65.0%

반응물

CCCCCCCCCCCC(C)=O
2-tridecanone
CC(C)c1cccc(C(C)C)c1N=C=O
2,6-diisopropylphenyl isocyanate
CC(C)[N-]C(C)C.[Li+]
lithium diisopropylamide

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타Purification by flash chromatography (silica gel, 15% EtOAc/hexane)

실험 절차

The title compound was prepared from 2-tridecanone (10.0 g, 0.050 mol), 2,6-diisopropylphenyl isocyanate (10.16 g, 0.050 mol) and lithium diisopropylamide (0.050 mol) using the procedure described in Example 1. Purification by flash chromatography (silica gel, 15% EtOAc/hexane) yielded 13.14 g (0.032 mol, 65%) of the desired product.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US05278326uspto-grants-1994_01