반응 #1281714

반응 방정식

p-chlorophenylhydrazine

ethyl 4-chloro-6-phenyl-5,6,7,8-tetrahydroquinoline-3-carboxylate

→

2-p-chlorophenyl-2,3,6,7,8,9-hexahydro-8-phenylpyrazolo[4,3-c]-quinolin-3(5H)-one

용매

n-butanol

반응 조건

후처리

1. 1
   온도is refluxed overnight
2. 2
   기타evaporated to dryness
3. 3
   기타The residue is triturated with ether
4. 4
   여과filtered
5. 5
   기타Collected solid
6. 6
   workup.DISSOLUTIONis dissolved in ethanol
7. 7
   농축concentrated to a smaller volume
8. 8
   온도cooled
9. 9
   기타is recrystallized from ethanol

실험 절차

A mixture of 1.2 g of p-chlorophenylhydrazine and 2.25 g of ethyl 4-chloro-6-phenyl-5,6,7,8-tetrahydroquinoline-3-carboxylate (Example 1e) in 100 mL of n-butanol is refluxed overnight, then evaporated to dryness. The residue is triturated with ether and filtered. Collected solid is dissolved in ethanol, decolorized with charcoal, concentrated to a smaller volume and cooled to deposit a solid, which is recrystallized from ethanol to yield 2-p-chlorophenyl-2,3,6,7,8,9-hexahydro-8-phenylpyrazolo[4,3-c]-quinolin-3(5H)-one, m.p. 333°-335°.

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