반응 #1280590

반응 방정식

N,N-dibenzyl-2-(1-(2,6-dimethylpyrimidin-4-yl)piperidin-4-yl)ethanamine

→

2-(1-(2,6-Dimethylpyrimidin-4-yl)piperidin-4-yl)ethanamine

수율 66.0%

용매

MeOH

반응 조건

후처리

1. 1
   여과the reaction mixture was filtered off over Celite
2. 2
   세척washed with MeOH (100 ml)
3. 3
   농축The filtrate was concentrated under reduced pressure
4. 4
   기타dried

실험 절차

A solution of N,N-dibenzyl-2-(1-(2,6-dimethylpyrimidin-4-yl)piperidin-4-yl)ethanamine (700 mg, 1.691 mmol, 1.0 eq) in MeOH (10 ml) was degassed for 30 minutes with nitrogen; 10% Pd(OH)2 (420 mg) was added and hydrogenation was carried out for 12 hours at RT. After monitoring by TLC, the reaction mixture was filtered off over Celite and washed with MeOH (100 ml). The filtrate was concentrated under reduced pressure and dried. Yield: 66% (260 mg, 1.11 mmol)

출처