반응 #1280520

반응 방정식

N-Benzyl-N-methyl-2-(1-(pyridin-4-yl)piperidin-4-yl)ethanamine

→

N-Methyl-2-(1-(pyridin-4-yl)piperidin-4-yl)ethanamine

수율 30.0%

용매

MeOH

반응 조건

후처리

1. 1
   기타degassed for 30 min with nitrogen
2. 2
   workup.ADDITION20% Pd—(OH)2 (200 mg) was added
3. 3
   여과the reaction mixture was filtered off over Celite
4. 4
   세척washed with MeOH (3×25 ml)
5. 5
   농축the filtrate was concentrated under reduced pressure

실험 절차

N-Benzyl-N-methyl-2-(1-(pyridin-4-yl)piperidin-4-yl)ethanamine (1.4 g, 3.63 mmol, 1 eq) was dissolved in MeOH (20 ml) and degassed for 30 min with nitrogen. 20% Pd—(OH)2 (200 mg) was added and hydrogenation was carried out for 2 h at RT under balloon pressure (H2). After monitoring by thin-layer chromatography, the reaction mixture was filtered off over Celite and washed with MeOH (3×25 ml), and the filtrate was concentrated under reduced pressure. Yield: 30% (240 mg, 1.09 mmol).

출처