반응 #1275

반응 방정식

sodium hydroxide

sulfuric acid

Trans-1,2-indandiol

acetonitrile

acetonitrile

Water

→

cis-1-amino-2-indanol

수율 63.0%

반응 조건

후처리

1. 1
   온도The mixture was gradually warmed to 20° C. and aged to 3 hours
2. 2
   온도the mixture heated to reflux
3. 3
   기타The resulting solid was removed by filtration

실험 절차

Trans-1,2-indandiol (1.5 g) was dissolved in acetonitrile (25 mL) cooled to 0° C., and concentrated sulfuric acid (1.1 mL) was added. The mixture was gradually warmed to 20° C. and aged to 3 hours. Water (2 mL) was added and the mixture heated to reflux. Concentrated aqueous sodium hydroxide was added to adjust the pH to 12. The resulting solid was removed by filtration to provide an aqueous acetonitrile solution of cis-1-amino-2-indanol (1.02 g, 63% yield).

출처