반응 #1269839

반응 방정식

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester

→

3-[(6-Amino-hexanoyl)-ethoxycarbonylmethyl-amino]-propionic acid ethyl ester

용매

piperidine

dimethylformamide

반응 조건

후처리

1. 1
   농축The reaction mixture is concentrated under vacuum, water
2. 2
   workup.ADDITIONis added to the residue
3. 3
   추출the product is extracted with ethyl acetate
4. 4
   기타The crude product is purified by conversion into its hydrochloride salt

실험 절차

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester AB (11.5 g, 21.3 mmol) is dissolved in 20% piperidine in dimethylformamide at 0° C. The solution is continued stifling for 1 h. The reaction mixture is concentrated under vacuum, water is added to the residue, and the product is extracted with ethyl acetate. The crude product is purified by conversion into its hydrochloride salt.

출처