반응 #1268693

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1-benzyl-4-(N-tert-butoxycarbonyl-N-isopropylamino)piperidine

→

title intermediate

수율 99.0%

4-(N-tert-Butoxycarbonyl-N-isopropylamino)piperidine

수율 99.0%

용매

ethanol

ethanol

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후처리

1. 1
   workup.ADDITIONThis solution was then added to a 2 L Parr flask
2. 2
   workup.ADDITIONcontaining
3. 3
   기타had been flushed with nitrogen for 15 minutes
4. 4
   여과The reaction mixture was filtered through a pad of Celite
5. 5
   세척the Celite washed with ethanol
6. 6
   농축The filtrate was then concentrated in vacuo

실험 절차

A solution of 1-benzyl-4-(N-tert-butoxycarbonyl-N-isopropylamino)piperidine (79.0 g, 0.24 mol) in ethanol (140 mL) was flushed with nitrogen for 15 minutes. This solution was then added to a 2 L Parr flask containing a mixture of 10% palladium on carbon (15.8 g; ca. 50% wt. water) in ethanol (100 mL), which solution had been flushed with nitrogen for 15 minutes. This reaction mixture was placed on a Parr Shaker under hydrogen at 50 psi for 24 hours. The reaction mixture was filtered through a pad of Celite and the Celite washed with ethanol. The filtrate was then concentrated in vacuo to afford 57.0 g of the title intermediate as a white solid (>99% yield).

출처